Front Cover: Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1 (ChemMedChem 15/2023)

The Front Cover represents the screening process for identifying novel inhibitors of the protein histidine phosphatase PHPT1. Illudalic acid, a fungal natural product derived from Omphalotus illudens (the Eastern American Jack-O’-Lantern mushroom, background) and its synthetic analogs are the most potent inhibitors of PHPT1 activity reported to date, and appear to be reversible, non-competitive inhibitors. The PHPT1 enzyme and its active site are shown separately (PDB 2HW4). Cover design by Dr. Megan E. Browning, Erykah Starr, Daniel Hansen and Dr. Gregory B. Dudley.More information can be found in the Research Article by Hanfei Wang, Amy M. Barrios et al.