Synthesis and Structure of the Inclusion Compound COF300‐ALA

Comprehensive Summary Finding a new multimolecular lattice inclusion host is still challenging. We report the synthesis and the crystal structure of the first example of an inclusion compound COF300‐ALA by using three‐dimensional covalent organic frameworks (3D‐COFs) as the multimolecular host lattice. The guest‐host dynamics upon inclusion and exclusion of the gust molecule are uncovered in a 3D covalent organic framework.