Cover Feature: A pH-Activatable Prodrug and Metal Prodrug Conjugate of Gossypol: Synthesis, Emergent Photophysical, Nanoscopic, Computational, and in-Vitro Cellular Studies (Chem. Eur. J. 28/2023)

Megha Biswas,Dipankar Singha,Malay Kumar Rana,Rakesh Kumar Pathak

Chemistry - A European Journal（2023）

引用 0|浏览0

暂无评分

摘要

Activatable molecular transformation: A highly stable and low-energy gossyzid-Zn (metal-prodrug) conjugate is unmasked in two stages: first into a moderately stable gossyzid (prodrug) and then into a highly active and high-energy gossypol drug capable of climbing the energy hill to destroy cancer cells in a targetable manner. More information can be found in the Research Article by R. K. Pathak and co-workers (DOI: 10.1002/chem.202203865).image

查看译文

关键词

active drug masking,coordination-driven structural confinement,Gossypol,metal-drug conjugates,pH activatable therapeutic action,prodrugs

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要