Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis

Background: Studies investigating the association between ITPKC rs28493229 polymorphisms and Kawasaki disease (KD) risk found inconsistent data. Thus, we performed this meta-analysis to combine and analyze the available studies to get a precise estimation of the association. Methods: Relevant studies identified in the PubMed, Web of Science, Scopus, and CNKI databases were used to perform a meta-analysis. Pooled odds ratios (OR) with a 95% confidence interval (95% CI) were calculated under fixed- and random-effects models to appraise the association. Results: A total of eight case-control studies with 2,721 KD cases and 5,307 controls were selected. The results showed a statistically significant association between ITPKC rs28493229 polymorphism and an increased risk of KD under all five genetic models, i.e., allele (C vs. G: OR = 1.434, 95% CI 1.209-1.700, P ≤ 0.001), homozygote (CC vs. GG: OR = 2.085, 95% CI 1.423-3.055, P ≤ 0.001), heterozygote (CG vs. GG: OR = 1.530, 95% CI 1.359-1.722, P ≤ 0.001), dominant (CC+CG vs. GG: OR = 1.490, 95% CI 1.229-1.806, P ≤ 0.001), and recessive (CC vs. CG + GG: OR = 1.799, 95% CI 1.231-2.629, P = 0.002) in the overall population. When stratified by country, there was a significant association among Taiwanese. Conclusion: Our meta-analysis results supported that the ITPKC rs28493229 polymorphism is strongly associated with susceptibility to KD.