Ps-bpc10-1: safety and efficacy of using cereal food (frugra®) to improve blood pressure and bowel health in patients with ckd

Background: Hypertension is known to increase the risk of developing cardiovascular disease, chronic kidney disease (CKD), and death. One of the main causes of hypertension is excessive salt intake. Frugra®, a cereal food that has a low salt content of 0.5 g per serving, may help reduce salt intake. Additionally, Frugra is rich in dietary fiber, thereby beneficial for CKD patients. Methods: We enrolled 11 patients who underwent maintenance hemodialysis (HD), and 20 non-dialysis CKD patients. The usual breakfast was replaced with Frugra for 8 weeks, and the effects on blood pressure, urinary toxins, bowel movements, and body composition were examined. Results: In HD patients, Frugra reduced BNP and significantly decreased systolic and diastolic blood pressure. In addition, almost all subjects showed improved bowel movements, and blood levels of indoxyl sulfate, a urea toxin derived from intestinal bacteria, were significantly reduced. In non-dialysis CKD patients, decreasing blood pressure levels, improvement in stool characteristics measured by bristol scale and improvement in bowel movements and indoxyl sulfate levels were also tended to be decreased. Conclusion: These results suggest that intake of Frugra in patients with CKD could be a useful tool for health and may contribute to the prevention of cardiovascular disease by correcting blood pressure and fluid retention, improving the intestinal environment, and lowering urinary toxins.