Pc016 / #697 perturbation-based tacs-eeg biomarkers of gamma activity in alzheimer’s disease

Annalisa Palmisano,Elisa Tatti, Luke Pezanko,Davide Cappon, Joanna Macome,Giacomo Koch,Carmelo Smeralda,Davide Rivolta,Georges El Fakhri,Álvaro Pascual‐Leone,Daniel Z. Press,Emiliano Santarnecchi

Neuromodulation: Technology at the Neural Interface（2022）

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摘要

Alzheimer’s disease (AD) is characterized by impaired inhibitory circuitry and GABAergic dysfunction, leading to reduced fast brain oscillations in the gamma band (γ, 30–90 Hz). Assessment of such activity could lead to the identification of diagnostic and/or prognostic biomarkers. The current study aimed to test a multimodal “Perturbation-based” transcranial Alternating Current Stimulation-Electroencephalography (tACS)-EEG protocol to detect γ alterations in patients with AD, and correlate individual responses to tACS with clinical phenotype.

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关键词

gamma activity,alzheimers disease,perturbation-based,tacs-eeg

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