Photocatalytic Regioselective [2 + 2 + 1] Radical Annulation of Alkenes with tert-Butyl Nitrite and gem-Dihalides

A visible-light photocatalytic regioselective [2 + 2 + 1] radical annulation reaction of alkenes, tert-butyl nitrite, and gem-dihalides has been developed. The protocol provides an efficient and practical approach to obtain isoxazolines in good yields under mild conditions. Significantly, gem-dihalides serve as C1 synthons, while cheap tert-butyl nitrite acts as an ideal “N–O” synthon.