Back Cover: Nucleus‐specific RNAi nanoplatform for targeted regulation of nuclear lncRNA function and effective cancer therapy (EXP2 5/2022)

Zheng‐Ming Huang,Shaomin Liu, N. Lu,Lei Xu, S. Qian,Zhuoshan Huang,Zhi-Quan Huang,Phei Er Saw, Xianzhu Xu

Exploration（2022）

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摘要

A nucleus-specific RNAi nanoplatform was developed by Xu et al. for targeted regulation of nuclear lncRNA function and effective cancer therapy. This nanoplatform could respond to the endosomal pH to expose NTPA/siRNA complexes for the nucleus-specific siRNA delivery, leading to a significant inhibition of nuclear lncNEAT2 expression and tumor growth.

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关键词

rnai nanoplatform,nuclear lncrna function,nucleus‐specific,effective cancer therapy

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