Promotion of Appropriate Use of Recombinant Thrombomodulin and Improvement of Infectious DIC Withdrawal Rate by Intervention of the Ward Pharmacist

Recombinant thrombomodulin (rTM) is used for the treatment of disseminated intravascular coagulation (DIC). We investigated the dosage pattern of rTM for DIC associated with infectious diseases during 2017 in Asahikawa Medical University Hospital. Consequently, some cases did not meet the criteria for dose reduction and were underdosed. Then, we developed dosage criteria for rTM and according to the criteria a ward pharmacist suggested dosage to physicians from 2018. This study investigated the pharmacist’s intervention by comparing the rTM dosage and DIC withdrawal rates in 2017 with those in 2018.