SARS-CoV-2 seroprevalence in a rural and urban community household cohort in South Africa, after the third wave, April-November 2021

Abstract By November 2021, after the third SARS-CoV-2 wave in South Africa, seroprevalence was 60% (95%CrI 56%-64%) in a rural and 70% (95%CrI 56%-64%) in an urban community; highest in individuals aged 13-18 years. High seroprevalence prior to Omicron emergence may have contributed to reduced severity observed in the 4 th wave. Article Summary Line In South Africa, after a third wave of SARS-CoV-2 infections, seroprevalence was 60% in a rural and 70% in an urban community, with case-to-infection, - hospitalization and -fatality ratios similar to the second wave.