Abstract 12519: Derivation of Coronary Age Based on Coronary Artery Calcification Score Compared to Chronological Age

Introduction: Besides reporting conventional calcium score, coronary age was suggested as an original function of cardiovascular risk. Hypothesis: In a primary prevention cohort, we sought to assess the reclassification provided by coronary arterial age derived from the Multi-Ethnic Study of Atherosclerosis- coronary artery calcification 10-year risk score (MESA-CACS). Methods: Consecutive patients (n=5324 ,age 57± 8 years ,76% male and 87% white) undergoing CACS screening in a primary prevention clinic between 3/2016 and 10/2021 were retrospectively included in this study. Coronary arterial age was calculated for the patients using the formula provided by Blaha M et al 2021 by solving for age from MESA-CACS 10-year risk = 1–0.99963exp(0.04555*Age+2.45). Results: The distribution of the difference between the calculated coronary age and the chronological age is presented in Fig 1a, with 1823 (62%) patients with CAC of 0 being downgraded by >20 years and 298 (29%) of patients with CAC >75 th percentile being upgraded by >20 years. The average difference between coronary age and chronological age (years) across the CAC percentile groups is -23.7, -18.3, -7.4, -0.2 and +12.8 years for CAC of 0, 1-25, 26-50, 51-75 and >75 th percentile, respectively (Figure 1b). Conclusions: The use of coronary age is a simplified method of explaining the MESA-CAC cardiac risk status for the patients. In our study, coronary age was lower by more than 20 years versus chronological age for CAC percentiles between 0 and 50, almost equal with CAC percentile 51-75 and greater than chronological age by more than 10 years for CAC percentile >75. Fig 1A: Distribution of coronary age classification compared to the chronological across the CACS percentiles 1B: Mean difference between coronary and chronological age across the CACS percentile