Abstract 11088: Childbirth Related Complications in Women With Hypertrophic Cardiomyopathy

Background. Women with hypertrophic cardiomyopathy (HCM) have higher risk of adverse cardiac events and obstetrics complications with labor and delivery (L&D). Data on HCM and peripartum complications are still scarce. We aimed to examine the maternal cardiovascular and obstetric outcomes of L&D in women with HCM in the United States. Methods. We identified 1,1655 mothers with HCM (age 29.5±6.2 years, 48% Caucasians) admitted to a hospital for childbirth from 2003-2018 according to Nationwide Inpatient Sample database. Results. Mode of delivery was Cesarean section (CS) in [702 (61%)] and mean length of stay was 5.5±6 days. There were two maternal deaths and a low rate of major adverse cardiac events (MACE) including cardiac arrest [n=11 (0.9%)], cardiogenic shock [n=10 (0.8%)], and ventricular tachycardia [n=35 (3%)]. Cardiopulmonary resuscitation, mechanical circulatory support, and temporary venous pacemaker rates were low at 0.75%, 0.4%, and 0.4% respectively. There was an increased rate of ARDS [n=45 (3.9%)], deep veins thrombosis [n=8 (0.7%)] and acute renal failure [n=14 (1.2%)]. Obstetric complications included abruption placenta [n=36 (3.14%)], preterm labor [n=193 (16.8%)], premature rupture of membranes [n=32 (2.8%)], pre-eclampsia/eclampsia [n=166 (14.37%)] and gestational hypertension [n=57 (4.9%)]. Post-partum hemorrhage occurred in [n=26 (2.2%)] of deliveries and maternal blood transfusion was needed in [n=77(6.7%)] of patients. Fetal distress, abnormal fetal heart rate and fetal growth retardation occurred in 5.5%, 9.8% and 1.3%, respectively. Conclusions. We were able to identify that there has been an increase in the number HCM over the past decade, however, there has been a decrease in maternal and fetal complications.