Scaling SARS-CoV-2 Wastewater Concentrations to Population Estimates of Infection

Abstract Monitoring the progression of SARS‐CoV‐2 outbreaks requires accurate estimates of infection rates. Estimation methods based on observed cases are biased due to changes in testing over time. Here we report an approach based upon scaling daily concentrations of SARS‐CoV‐2 RNA in wastewater to infections that produces representative estimates due to the consistent population contribution of fecal material to the sewage collection system.