Analysis of Immune Response of Chicken Primary Cells by Infection With Korean IBV Strain

Abstract Infectious bronchitis virus (IBV), an avian coronavirus, is highly contagious, which develops acute pathogenesis in multiple organs. Frequent recombination of spike (S) glycoprotein leads to vaccine strategies insignificant. To understand IBV pathogenesis, we analyzed genetic distance of the Korean IBV isolate to different coronaviruses, including SARS-Cov2. For comprehensive information of the immune responses during IBV infection, we infected primary chicken embryonic kidney cells and performed transcriptome analysis. We observed functional pathways for innate immunity are associated and confirmed mRNA expressions of element genes that coordinate early immune responses. Immune profile of the host cell may assist vaccine development.