Meta-Analysis of Topical Tranexamic Acid in Posterior Lumbar Surgery for Patients with Lumbar Degenerative Diseases

Posterior lumbar surgery often entails laminectomy, decompression, fusion, and instrumentation, which may contribute to significant blood loss during the perioperative period. Excessive blood loss may increase the need for blood transfusion and the incidence of transfusion-related complications such as infections, allergic reactions, and acute lung injury [1]. Moreover, significant postoperative blood loss can prolong the duration of tube drainage and hospital stay [2]. Thus, ensuring an effective and safe management of blood loss during posterior lumbar surgery has become an important issue for spinal surgeons.