snPATHO-seq: unlocking the pathology archives

Taopeng Wang,Kate Harvey, Javier Escudero Morales, Beata Kiedik,Ghamdan Al-Eryani,Alissa C. Greenwald, Nikolaos Kalavros, Felipe SegatovDezem, Yuling Ma,Yered Pita-Juarez, Kellie Wise,Cyril Degletagne, Anna Elz, Jack Johanneson,Fiona Pakiam, Heeju Ryu,Evan W Newell,Laurie Tonon, Andrew Kohlway, Tingsheng Drennon, Az Hadadianpour, Jawad Abousoud, Ryan Scott, Paul Lund, Jens Durruthy, Andres F Vallejos, Dominik Kaczorowski, Joanna Warren,Lisa M Butler,Sandra O'Toole,Jasmine T Plummer,Ioannis Vlachos,Joakim Lundeberg,Alexander Swarbrick,Luciano G Martelotto

biorxiv（2023）

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摘要

Formalin-fixed paraffin-embedded (FFPE) samples are valuable but underutilized in single-cell omics research due to their low DNA and RNA quality. In this study, leveraging recent single-cell genomic technology advances, we introduce a versatile method to derive high-quality single-nucleus transcriptomic data from FFPE samples. ### Competing Interest Statement The authors have declared no competing interest.

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