Prediction of high-grade serous ovarian cancer (HGSC) with mtDNA genetic variation

Early detection of ovarian cancer remains elusive. Recently there have been some reports indicating the possibility of using genetic variation in the detection of several malignancies, including using variation from mitochondrial DNA (mtDNA). The objective of this pilot study was to assess if a genetic variation of mtDNA can identify high-grade serous ovarian cancer (HGSC). Additionally, we assessed the effect of significant variants on gene expression.