Prurigo nodularis blood signature is characterized by increases in IL-13 and caspase 8

Teresa Ju,Angelina Labib,Leigh Nattkemper,Sarah Engle,Autum Auxier,Nathan Hahn,Sean Sissons,Jonathan Sims,Zhe Sun,Angela Okragly,Gil Yosipovitch

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY（2023）

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摘要

Background Prurigo nodularis (PN) is a severely pruritic inflammatory skin condition characterized by symmetrically distributed hyperkeratotic nodules. Immune dysregulation is suggested to underly the mechanism of itch in PN with type 2 immune mediators found to be upregulated in the PN lesional skin (1). However, no study characterizing the systemic inflammatory signature of PN has yet been conducted.

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prurigo nodularis blood signature,caspase

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