Spatial transcriptomic analysis of hidradenitis suppurativa dermal tunnels: A pilot study using digital spatial profiling highlights the invasive nature of hidradenitis tunnel epithelium

Introduction: Hidradenitis suppurativa (HS) is a chronic, inflammatory disease characterized by painful nodules and abscesses that progress into draining tunnels.(1) The pathophysiology of HS is incompletely understood and to date transcriptomic studies have focused on bulk analysis of tissue specimen.