A Review on Synthesis and Biological Applications of Quinoline Derivative as Fused Aromatic Compounds

Quinoline is a N-containing heterocyclic organic compounds with significant biological importance in pharmaceuticals field as well as natural products. They exhibit excellent pharmacological activities. To synthesize quinoline and their derivatives several synthetic methods have reported, such as conventional method, ultrasonic method, microwave (MW) irradiation method, with or without catalytic reaction, which have various pharmacological and biological activities, such as antibacterial, antifungal, anticancer, anti-HIV, antimalarial, antitumor, and anti-inflammatory activity. The objective of this review is to compile various synthetic methods were used for the formation of the Quinoline derivatives and their biological importance, such as antibacterial, anticancer, anti-microbial, antimalarial, antileishmanial, antifungal, and anti-inflammatory during 2010-2023, which will help the researchers how are working in this area. [Graphical Abstract]