Palladium-Catalyzed anti-Markovnikov Halosulfonamidation of Unactivated Alkene

Palladium-catalyzed regioselective amination of unactivated alkene remains a challenge and is of great interest. Herein, a three-component coupling of unactivated alkene, sulfonamide, and N-halo compounds accessing vicinal haloamine has been conceived. This aminohalogenation represents a modular and regioselective strategy. The electrophilic halogenating agent enables regioselective anti-Markovnikov aminopalladation and facilitates subsequent halogenation events. And this protocol is characterized by gram-scale syntheses and late-stage functionalizations. Of note, the recovered byproduct phthalimide allows for reusing by conversion to the starting material.