Plasmid-encoded VCC-1 -lactamase in a clinical isolate of Aeromonas caviae

Vibrio cholerae carbapenemase (VCC-1) is a chromosomal encoded class A carbapenemase thus far reported in environmental Vibrio cholerae isolates. Here, we report the first isolation of a bla(VCC-1)-carrying Aeromonas caviae from a clinical sample in Israel. The isolate was resistant to all beta-lactam agents, including carbapenems. The bla(VCC-1) was located on a large plasmid. GC content suggests that the origin of the bla(VCC-1) gene is neither Aeromonas nor Vibrio spp. but an unknown progenitor.