Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs

Alexander Kastner,Theresa Mendrina,Tomer Babu,Subhendu Karmakar,Isabella Poetsch,Walter Berger,Bernhard K. Keppler,Dan Gibson,Petra Heffeter,Christian R. Kowol

Inorganic Chemistry Frontiers（2024）

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摘要

An albumin-binding cisplatin(iv)-gemcitabine complex was step-by-step improved based on stability, reduction, albumin-binding and in vivo data yielding a carboplatin(iv) complex with distinctly improved overall survival and anticancer activity.

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