Buprenorphine Versus Methadone for Opioid Use Disorder in Pregnancy

(N Engl J Med. 2022;387:2033–2044) Opioid use during pregnancy has been on the rise since 2000. The standard care for opioid use disorder during pregnancy is either buprenorphine or methadone treatment, which both have been shown to improve maternal and neonatal outcomes. Buprenorphine may have greater benefits, yet data is limited. This study aimed to analyze the risk of adverse outcomes for mother and baby with buprenorphine treatment compared to methadone treatment for opioid use during pregnancy.