Intramuscular ketamine vs. midazolam for rapid risk-reduction in suicidal, depressed emergency patients: Clinical trial design and rationale

•Randomized, midazolam-controlled trial (RCT) of intramuscular (IM) ketamine in suicidal, depressed emergency department (ED) patients.•Outcomes: feasibility, safety, efficacy for reducing suicidality, depression.•Target (N = 90) adults in a major depressive episode warranting hospitalization for suicide risk.•Trial progress (n = 53) shows diverse sample tending towards young adults.