Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating T _reg cells

M. Feng, J. Q. Jin, L. Xia, T. Xiao, S. Mei, X. Wang,X. Huang,J. Chen, M. Liu,C. Chen, S. Rafi,A. X. Zhu, Y.-X. Feng, D. Zhu

Science Advances（2019）

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摘要

Pharmacological inhibition of β-catenin/BCL9 interaction modulates T reg cells and improves immunotherapy.

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Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating T reg cells