Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing

(Cell Stem Cell 27, 396–412.e1–e6; September 3, 2020) In the originally published version of our manuscript, Figure 5B contained a misspelling of the gene name Prrx1 and we inadvertently swapped the order of the two corresponding AUC plots shown for CD59a and Prrx1. To address this, we have now corrected the misspelling and repositioned each plot with its appropriate gene in the amended figure below and in our manuscript online. We apologize for the oversight and any resulting confusion.Figure 5Distinct Regulatory Network Activity Is Enabled by Preferential Chromatin Accessibility to Regeneration-Associated TFs (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound HealingAbbasi et al.Cell Stem CellAugust 4, 2020In BriefAbbasi et al. show that interfollicular (but not hair follicle-associated) mesenchymal progenitors generate the bulk of reparative fibroblasts in skin wounds. Wound microenvironments remodel the regulatory landscape of recruited fibroblasts, resulting in regeneration centrally and scar-formation peripherally. Pharmacogenetic modulation of regeneration-associated regulators within wound-activated fibroblasts modifies healing outcomes. Full-Text PDF Open Archive