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Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL -rearranged AML

Isabel Morgado-Palacin,Amanda Day,Matilde Murga,Vanesa Lafarga,Marta Elena Antón,Anthony Tubbs,Hua-Tang Chen, Aysegul V. Ergen,Rhonda Anderson,Avinash Bhandoola,Kurt G. Pike,Bernard Barlaam,Elaine Cadogan,Xi Wang,Andrew J. Pierce, Chad Hubbard,Scott A. Armstrong,André Nussenzweig,Óscar Fernández-Capetillo

Science Signaling（2016）

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摘要
Chemotherapy-resistant acute myeloid leukemia may respond to inhibition of ATR or ATM.
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关键词
kinase activities,aml,antitumoral activity,atr
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