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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

Luc de Waal,Timothy A Lewis,Matthew G Rees,Aviad Tsherniak,Xiaoyun Wu,Peter S Choi,Lara Gechijian,Christina Hartigan,Patrick W Faloon,Mark J Hickey,Nicola Tolliday,Steven A Carr,Paul A Clemons,Benito Munoz,Bridget K Wagner,Alykhan F Shamji,Angela N Koehler,Monica Schenone,Alex B Burgin,Stuart L Schreiber,Heidi Greulich,Matthew Meyerson

Nature Chemical Biology（2015）

引用 66|浏览0
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摘要
Phenotypic screening in cancer cell lines combined with chemogenomics analysis reveals a correlation between DNMDP sensitivity and increased PDE3A expression. DNMDP binding to PDE3A induces a switch resulting in interactions with SLFN12 and SIRT7.
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关键词
pde3a,cancer-cytotoxic
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