Hematopoietic stem cell niches

Hematopoietic stem cells (HSC) reside at the apex of the hematopoietic hierarchy, with self-renewal and differentiation potential, and are widely used in clinic. Studies in the past few decades have confirmed that the functional characteristics of HSC are not only controlled by intrinsic factors, but also supported and nourished by extrinsic environment (or niche). In recent years, advances in imaging and genetic tools have rapidly increased our understanding of HSC niches. Here, we provide an overview on recent progress in the field of hematopoietic microenvironment.