A phase I trial of oncolytic adenovirus ICOVIR-5 administered intravenously to melanoma patients

Margarita García,Rafael Moreno,Marta Gil,Manel Cascalló,María Ochoa de Olza,Carmen Cuadra, Josep Maria Piulat,V. Navarro,Marta Domènech,Ramón Alemany,Ramón Salazar

Human gene therapy. Clinical development（2018）

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摘要

Oncolytic viruses represent a unique type of agents that combine self-amplification, lytic and immunostimulatory properties against tumors. A local and locoregional clinical benefit has been demons...

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adenovirus

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