Time to move from prognostication to diagnosis and treatment of heart disease in acute exacerbation of COPD
The European respiratory journal(2017)
摘要
In this edition of the journal, Laribi et al . [1] report the incremental value of biomarkers relative to the CURB-65 score for predicting 30-day mortality in acute exacerbations of chronic obstructive pulmonary disease (COPD). The derivation cohort of 356 elderly patients combined four single centre studies of consecutive emergency department attendees, 12% being subsequently admitted to the intensive care unit (ICU). Cardiovascular comorbidity was common (41% hypertension, 20% heart failure). The primary end-point of 30-day mortality occurred in 27 patients (7.6%), congruent with existing literature reporting variable rates of 4.6–12% short-term mortality [2, 3]. The authors focus on the performance of myocardial injury markers, recognising that cardiac disease is a common cause of death in patients with COPD [4]. The link between copeptin, troponin and mortality indicates a strong need for examining cardiac mechanisms in AECOPD
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关键词
heart disease,acute exacerbation,prognostication,diagnosis
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