Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures

Xiaodong Wu,Guangkun Tan, Sha Wang,Haican Liu,Jinghui Yang,Yinjuan Guo,Xin Shen,Zheyuan Wu,Hongbo Shen,Fangyou Yu

Microbiology spectrum（2022）

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摘要

In this study, we used whole-genome sequencing (WGS) from early positive liquid (MGIT) cultures instead of solid cultures to predict drug resistance of 182 Mycobacterium tuberculosis complex (MTBC) clinical isolates to predict drug resistance using the TB-Profiler informatics platform. Our study indicates that WGS may be a promising method for predicting MTBC resistance using early positive liquid cultures.

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关键词

<i>mycobacterium tuberculosis</i>,complex drug resistance,whole-genome

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