The Avian Retroviral Receptor Tva Mediates the Uptake of Transcobalamin Bound Vitamin B ₁₂ (Cobalamin)

We demonstrate that the ASLV receptor Tva participates in the physiological uptake of TC-Cbl because the viral infection suppresses the uptake of Cbl and vice versa. Our results pave the road for future studies addressing the following issues: (i) whether a virus infection can be inhibited by TC-Cbl complexes in vivo , and (ii) whether any human virus employs the human TC-Cbl receptor CD320.