Excess TGF-β mediates muscle weakness associated with bone metastases in mice
David L Waning,Khalid S Mohammad,Steven Reiken,Wenjun Xie,Daniel C Andersson,Sutha John,Antonella Chiechi,Laura E Wright,Alisa Umanskaya,Maria Niewolna,Trupti Trivedi,Sahba Charkhzarrin, Pooja Khatiwada,Anetta Wronska, Ashley Haynes,Maria Serena Benassi,Frank A Witzmann,Gehua Zhen,Xiao Wang,Xu Cao,G David Roodman,Andrew R Marks,Theresa A Guise Nature Medicine（2015）
摘要
Metastasis-mediated osteolysis results in excess release of TGF-β that, in turn, leads to muscle weakness.
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关键词
bone metastases,muscle
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