SomaticCALR Mutations in Myeloproliferative Neoplasms with NonmutatedJAK2 Jyoti Nangalia , Charles E. Massie , E. Joanna Baxter , Francesca Nice , Gunes Gundem , David C. Wedge , Edward Avezov , J. Li , Karoline Kollmann , David G. Kent , Athar Aziz , Anna L. Godfrey , Jonathan Hinton , Iñigo Martincorena , Peter Van Loo , Amy V. Jones , Paola Guglielmelli , Patrick Tarpey , Heather P. Harding , John D. Fitzpatrick , Calum T Goudie , Christina A. Ortmann , Stephen J. Loughran , Keiran Raine , Daniel Jones , Adam Butler , Jon W. Teague , Sarah O’Meara , Stuart McLaren , Michele Leonardo Bianchi , Yvonne Silber , Dimitra Dimitropoulou , David Bloxham , Laura Mudie , Mark Maddison , Ben Robinson , Clodagh Keohane , Cathy MacLean , Kate Hill , Kim Orchard , Sudhir Tauro , Ming‐Qing Du , Mel Greaves , David Bowen , Brian J. P. Huntly , Claire Harrison , Nicholas C. P. Cross , David Ron , Alessandro M. Vannucchi , Elli Papaemmanuil , Peter J. Campbell , Anthony Green The New England Journal of Medicine（2013）
摘要
Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnosis of these neoplasms remains a challenge.
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myeloproliferative neoplasms, somatic<i>calr</i>mutations, somatic<i>calr</i>mutations
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