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Electroselective C(sp3)–H deuteration of isoindolinones

Qiansong Gao,Lianyou Zheng,Shulin Ning, Lingling Shi,Wei Cheng, Mian Liu,Jinbao Xiang

Organic chemistry frontiers（2023）

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摘要
An efficient paired electrochemical method for selective deuteration of isoindolinones was realized via H/D exchange. Its utility has been well exemplified in the late-stage modification of bioactive molecules and their further transformation.
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