Cystic fibrosis airway inflammation enables elexacaftor/ tezacaftor/ivacaftor-mediated rescue of N1303K CFTR mutation

Martina Gentzsch, Brooke Baker,Deborah M. Cholon, Charissa W. Kam,Cameron J. McKinzie, Katherine A. Despotes,Susan E. Boyles,Nancy L. Quinney,Charles R. Esther,Carla M. P. Ribeiro

ERJ OPEN RESEARCH（2024）

引用 0|浏览4

暂无评分

摘要

Rescue of N1303K CFTR by highly effective modulator therapy (HEMT) is enabled by CF airway inflammation. These findings suggest that evaluation of HEMT for rare CFTR mutations must be performed under inflammatory conditions relevant to CF airways. https://bit.ly/3tTcoJE.

查看译文

关键词

cystic fibrosis airway inflammation,cystic fibrosis,mutation,ivacaftor-mediated

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要