Survival and reoperation in acute aortic syndromes—a single center experience of 912 patients

Abstract OBJECTIVES Acute aortic syndromes are associated with poor outcomes, despite diagnostic and therapeutic advances. We analyzed trends in volumes and outcomes from 2000 to 2021. METHODS The study population includes 494 type A acute aortic syndromes (TAAAS) (54.2%) and 418 type B acute aortic syndromes (TBAAS) (45.8%). Primary outcomes were in-hospital mortality, long-term survival and freedom from aortic reoperation. RESULTS Regardless the type of acute aortic syndrome, patient volumes increased over time. Patients with TBAAS were older, more likely to have comorbid conditions and previous cardiac surgery (p < 0.001), while cerebrovascular accidents were more frequent in TAAAS (p < 0.05). Among TAAAS, 143 (28.9%) required total arch and 351 (71.1%) hemiarch replacement. TBAAS management was medical therapy in 182 (43.5%), endovascular in 198 (47.4%) and surgical in 38 (9.1%) cases. Overall in-hospital mortality was 14.6% (18.2% in TAAAS [95% CI 14.4–21.2%] vs 10.7% in TBAAS [95% CI 7.8%–13.7%]; p = 0.0027). After propensity score adjustment, in-hospital mortality exhibited a significantly decreasing trend from 2000 to 2021 (p < 0.001) in TAAAS and TBAAS. 1-, 5- and 10-year survival was 74.2%, 62.2% and 45.5% in TAAAS and 75.4%, 60.7% and 41.0% in TBAAS (p = 0.975), with no differences among treatment strategies. The adjusted cumulative reoperation risk at 10 years was more than twofold in TBAAS vs TAAAS (9.5% vs 20.5%, HR = 2.30, 95% I 1.31–4.04). CONCLUSIONS In the last decades, better patient triage and surgical/endovascular techniques led to substantial improvements in the management of acute aortic syndrome, with reduction in early mortality and reoperation rate. However, long-term mortality is still >50%.