Development of Novel Models of Aggressive Variants of Castration-resistant Prostate Cancer

Ludovic Bigot,Jonathan Sabio,Loic Poiraudeau,Maxime Annereau,Naoual Menssouri,Carole Helissey,Olivier Déas, Marine Aglave, Tony Ibrahim,Cédric Pobel, Catline Nobre,Claudio Nicotra,Maud Ngo-Camus,Ludovic Lacroix,Etienne Rouleau,Lambros Tselikas,Jean-Gabriel Judde,Anne Chauchereau,Alice Bernard-Tessier,Anna Patrikidou

European Urology Oncology（2023）

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摘要

Our study has identified models of aggressive variants of metastatic prostate cancer that may arouse interest among the scientific community. These models are essential for preclinical and translational studies aimed at testing novel therapeutics and identifying mechanisms of resistance.

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关键词

PDX models,Organoids (PDXO, PDO),Aggressive prostate cancer resistance,Translational research,Preclinical research,Prostate cancer single cell RNA sequencing,Drug screening

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