Formulation and in vitro evaluation of zafirlukast pulsatile drug delivery system

The aim of this study was to explore the feasibility of time dependent pulsatile drug delivery system of Zafirlukast, is to blocks the action of the cysteinyl leukotrienes on theCysLT1receptors, thus reducing constriction of the airways, build-up of mucus in the lungs and inflammation of the breathing passages.A satisfactory attempt was made to develop pulsatile system of Zafirlukast and evaluated it.From the reproducible results obtained from the executed trails of core and press coated tablets it can be concluded that drug like Zafirlukast and excipients like MCC, Lycoat, SSG, Ludiflash, and Talc were used to prepare pulsatile formulation.Prepared pulsatile drug delivery systems were evaluated for hardness, friability, weight variation, drug content uniformity, drug-polymer interaction, invitro drug release.Various formulations prepared, formulationF6 were selected as optimized formulations.