Neutrophil-to-lymphocyte ratio, factor VIII and antithrombin III: Inflammatory-clotting biomarkers in glioma

There is an urgent need for sufficiently sensitive, specific and routine biomarkers for glioma, tumour of glial cells. The main purpose of this study was to identify possible biomarkers in glioma comparing some routine coagulation factors and Neutrophil-to-lymphocyte ratio (NLR) among the following subgroups: a) glioma and MS patients, controls; b) non-recurrent and recurrent glioma patients. As a secondary endpoint we assessed if these markers could be predictive of overall (OS) and progression-free survival (PFS) in glioma patients.