Mp02-05 symptoms of central sensitization are associated with worse lower urinary tract symptoms in men

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction I (MP02)1 Sep 2021MP02-05 SYMPTOMS OF CENTRAL SENSITIZATION ARE ASSOCIATED WITH WORSE LOWER URINARY TRACT SYMPTOMS IN MEN Angela Senders, Kamran Sajadi, Scott Bauer, Thu Le, Ryan Wexler, Yiyi Chen, Barry Oken, and Lynn Marshall Angela SendersAngela Senders More articles by this author , Kamran SajadiKamran Sajadi More articles by this author , Scott BauerScott Bauer More articles by this author , Thu LeThu Le More articles by this author , Ryan WexlerRyan Wexler More articles by this author , Yiyi ChenYiyi Chen More articles by this author , Barry OkenBarry Oken More articles by this author , and Lynn MarshallLynn Marshall More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001963.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Central sensitization (CS) is an impairment in the processing of sensory information that results in ongoing hypersensitivity to nociceptive and other somatic signals. CS has been examined as a possible mechanism of overactive bladder among women, but studies of CS and urinary symptoms among men are lacking. Our objective was to determine the association between CS symptoms and lower urinary tract symptoms (LUTS) among men. METHODS: We conducted a cross-sectional study using an electronic survey. From June-August 2020, we contacted 209 men, age 18 years or older, who had received urodynamic testing for LUTS in the past 3 years at our institution’s adult urology clinic. Of these, 75 did not respond, 43 declined, and 91 (44%) consented. We obtained demographics, history of diagnosed neurological conditions, chronic pain syndromes, current bladder or genital pain, the American Urological Association Symptom Index (AUASI) and the Central Sensitization Inventory (CSI). The CSI is a 25-item questionnaire quantifying symptoms commonly reported by people with CS, with the sum of items resulting in a total score of 0-100 points. A CSI score of ≥40 indicates moderate-to-severe CS-related symptoms. We used multivariable linear regression to model the association between moderate-to-severe CS and AUASI score. We estimated regression coefficients (β) and 95% confidence intervals (CI) adjusted first for age. The final model was adjusted for age, existing neurologic conditions (multiple sclerosis, Parkinson’s disease), chronic prostatitis (CP), chronic bladder or pelvic pain, and pain with urination or ejaculation in the past week. RESULTS: Among 90 men with complete data, the mean (standard deviation, sd) age was 66 (14) years, 76 (84%) were non-Hispanic white, 27 (30%) had CSI scores ≥ 40, and the mean (sd) AUASI score was 15 (9) points. Controlled for age, the AUASI score averaged 8 points greater among men with CS compared to men without CS (β=8.1, 95% CI: 4.3, 11.9). The positive association remained in the final model (β=7.6, 95% CI: 3.4, 11.7). When restricted to 53 men without neurologic conditions, CP, pain syndromes, or urination or ejaculation pain, the association remained (age-adjusted β=8.7, 95% CI: 2.5, 14.9). CONCLUSIONS: Symptoms suggestive of moderate-to-severe CS were common among men with a recent history of urodynamic testing for LUTS and associated with significantly greater AUASI scores. The association was independent of existing neurologic and chronic pain conditions including CP. Objective assessment for the presence of CS among men with LUTS is warranted. Source of Funding: Unfunded © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e13-e13 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Angela Senders More articles by this author Kamran Sajadi More articles by this author Scott Bauer More articles by this author Thu Le More articles by this author Ryan Wexler More articles by this author Yiyi Chen More articles by this author Barry Oken More articles by this author Lynn Marshall More articles by this author Expand All Advertisement PDF downloadLoading ...