Back Cover: Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling (Angew. Chem. Int. Ed. 25/2021)

Bicyclic peptidomimetics bind the transcriptional coactivator β-catenin. A structure-based design strategy has been applied to minimize a 52 amino acid binding motif into bicyclic 16-mer β-sheet mimetics. The biologically most active mimetic exhibits robust cellular uptake and inhibits Wnt signaling in a cell-based assay, as reported by Tom N. Grossmann and co-workers in their Research Article on page 13937.