Advances in Antimicrobial Peptides with an approach to molecular structure prediction

Antimicrobial peptides (AMP) are molecules involved in the innate immune system of almost all living organisms. They are potent agents with diverse structural and antimicrobial properties, which represent one of the most promising future drug candidate for combating infections and antimicrobial drug resistance. They have also a wide spectrum of activity against a large number of pathogenic microorganisms, multiple mechanisms of action and a low potential for resistance. Numerous AMPs have been isolated from natural sources and many others have been de novo designed and synthetically produced. This review provide insight into antimicrobials properties of AMPs, focusing in antibacterial molecules, that provides better understanding of versatile biological properties of such peptides. Also, provide a short insight into chemical modifications, characterization and the principal methods for protein structure prediction of AMPs.