Cu²⁺-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation

Joana S. Cristóvão,Guilherme G. Moreira,Filipe E. P. Rodrigues,Ana P. Carapeto,Mario S. Rodriguès,Isabel Cardoso,António E. N. Ferreira,Miguel Machuqueiro,Günter Fritz,Cláudio M. Gomes

Chemical Communications（2021）

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摘要

A mechanism of chemical regulation of the S100B chaperone via Cu²⁺ induced assembly of S100B cross-linked oligomers with enhanced anti-amyloid aggregation activity.

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关键词

disulfide,enhanced chaperone activity,tetramers,polymerization,cross-linked

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Cu2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation

Cu²⁺-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation