Novel model to study the physiological effects of temporary or prolonged sex steroid deficiency in male mice

Na Ri Kim, Radwa Khalil,Karel David,Antonio L’Abbate,Dieter Schollaert,Ludo Deboel,Erik Van Herck,Wardenier Nele,Martine Cools,Brigitte Decallonne,Frank Claessens,Vanessa Dubois,Dirk Vanderschueren

American Journal of Physiology-endocrinology and Metabolism（2021）

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摘要

We developed a rodent model of chemical castration, which can be used as an alternative to surgical castration. Moreover, the transient nature of the intervention enables to study the effects of delayed puberty and reversibility of sex steroid deficiency.

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关键词

prolonged sex steroid deficiency,male mice,physiological effects

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