Novel function of Trim44 promotes an antiviral response by stabilizing VISA (P1417)

Abstract VISA functions as a critical adaptor in the regulation of both the production of type I interferons (IFNs) and the subsequent control of the innate antiviral response. In this report, we demonstrate that Trim44 interacts with VISA and promotes VISA-mediated antiviral responses. The overexpression of Trim44 enhances the cellular response to viral infection, whereas Trim44 knockdown yields the opposite effect. Trim44 stabilizes VISA by preventing VISA ubiquitination and degradation. These findings suggest that Trim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA.