Restoring Single-Molecule Localizations with Wavefront Sensing Adaptive Optics for Deep-Tissue Super-Resolution Imaging

Hyesung Park,Yonghyeon Jo,Minsu Kang,Jin Hee Hong,Sang‐Hee Shim,Wonshik Choi

Imaging and Applied Optics Congress 2022 (3D, AOA, COSI, ISA, pcAOP)（2022）

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摘要

We measured the sample-induced aberration using reflectance signal without resorting to fluorescence detection and corrected it. It enabled deep-tissue single-molecule localization microscopy even when the aberration was too severe to initiate localization.

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关键词

wavefront sensing adaptive optics,imaging,single-molecule,deep-tissue,super-resolution

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