Vaginal Progesterone Is as Effective as Cervical Cerclage to Prevent Preterm Birth in Women With a Singleton Gestation, Previous Spontaneous Preterm Birth, and a Short Cervix: Updated Indirect Comparison Meta-analysis

(Abstracted from Am J Obstet Gynecol 2018;219(1):10–25) It is widely accepted that preterm birth is a syndrome caused by several pathological processes such as infection, vascular and decidual disorders, uterine overdistension, breakdown of maternal fetal tolerance, a decline in progesterone action, and cervical disease. A previous spontaneous preterm birth is a well-known risk factor for recurrent spontaneous preterm delivery.